Evolution of the Fgf and Fgfr gene families.

By N. Itoh, D. Ornitz. Trends in Genetics, 2004

1,107 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d33ed5323d43783ace5201f86d9863e684d743fb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. M. Mohammadi
2. N. Itoh
3. A. Beenken
4. D. Ornitz
5. M. Kuro-o

In Molecular Biology

1. M. Mohammadi
2. A. Beenken
3. N. Itoh
4. D. Ornitz
5. M. Kuro-o
6. D. Mangelsdorf

Citations in the corpus

• Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease. (2011, background): “familes are identical to the human Fgf gene subfamilies (1, 12).”
• Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice (2009, background): “It is most closely related to FGF19 and FGF23, sharing 30–35% amino acid sequence homology (1).”
• The FGF family: biology, pathophysiology and therapy (2009, positive): “jpg" NDATA ITEM> ]> There are 18 mammalian fibroblast growth factors (FGF1–FGF10 and FGF16–FGF23) which are grouped into 6 subfamilies based on differences in sequence homology and phylogeny: FGF1 and FGF2 ; FGF3, FGF7, FGF10, FGF22; FGF4 , FGF5 and FGF6; FGF8 , FGF17 and FGF18; ”
• Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis. (2005, background): “Since then, 22 structurally-related members of the FGF family have been identified [8].”
• Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans (2008, background): “More recently, three members of this family, including FGF19 (FGF15 in the mouse), FGF21, and FGF23, have emerged as endocrine factors involved in metabolic regulation (6,7).”
• Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. (2010, methodology): “Based on phylogenetic analysis, the mouse and human FGF families can be divided into seven subfamilies: the FGF1 subfamily consisting of FGF1 and FGF2; the FGF4 subfamily consisting of FGF4, -5, and -6; the FGF7 subfamily consisting of FGF3, -7, -10, and -22; the FGF8 subfamily consisting of FGF8, -”
• Mechanisms underlying differential responses to FGF signaling. (2005, background): “The FGF family of ligands includes twenty-two members in humans and mice [7,8].”