The FGF family: biology, pathophysiology and therapy
By A. Beenken, M. Mohammadi. Nature reviews. Drug discovery, 2009
1,857 citations recorded by the source corpus.
The family of fibroblast growth factors (FGFs) regulates a plethora of developmental processes, including brain patterning, branching morphogenesis and limb development. Several mitogenic, cytoprotective and angiogenic therapeutic applications of FGFs are already being explored, and the recent discovery of the crucial roles of the endocrine-acting FGF19 subfamily in bile acid, glucose and phosphate homeostasis has sparked renewed interest in the pharmacological potential of this family. This Review discusses traditional applications of recombinant FGFs and small-molecule FGF receptor kinase inhibitors in the treatment of cancer and cardiovascular disease and their emerging potential in the treatment of metabolic syndrome and hypophosphataemic diseases.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/8e6d18e58bf57b2e0f053b8663d9c2301c707820
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In Genetics
In Molecular Biology
- Rakesh K. Jain
- Peter Carmeliet
- N. Itoh
- D. Ornitz
- N. Ferrara
- J. Joyce
- Dai Fukumura
- Triantafyllos Stylianopoulos
Citations in the corpus
- Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease. (2011, background): “Abbreviations: BMP, bone morphogenetic protein; FGF, fibroblast growth factor; FGFR, FGF receptor; MAPK, mitogen-activated protein kinase; PCR, polymerase chain reaction; PI3K, phosphatidylinositol 3-kinase; PLCg, phospholipase Cg; STAT, signal transducer and activator of transcription.”
- Recent advances in bone tissue engineering scaffolds (2012, background): “FGFs are released from the ECM by heparinases and regulate cellular proliferation, survival, migration and differentiation [12]”
- Molecular mechanisms and clinical applications of angiogenesis (2011, background): “The FGF superfamily The superfamily of FGFs and their receptors controls a wide range of biological function”