Oxidative stress and Alzheimer disease.
By Y. Christen. American Journal of Clinical Nutrition, 2000
1,151 citations recorded by the source corpus.
Subfields: Complementary and alternative medicine, Physiology, Rheumatology
View Paper: https://www.semanticscholar.org/paper/d319de76add65f356aa9407919bf86a7a8781590
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In Complementary and alternative medicine
In Physiology
Citations in the corpus
- Free Radicals, Antioxidants in Disease and Health (2008, background): “In a disease such as Alzheimer’s, numerous experimental and clinical studies have demonstrated that oxidative damage plays a key role in the loss of neurons and the progression to dementia (19).”
- Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. (2002, neutral): “AGROWING BODY OF EVIDENCE suggests that oxidative processes may be involved in the etiology of Alzheimer disease (AD).(1) Accumulated damage to lipid membranes and DNA by oxygen free radicals and reactive oxygen species is thought to disrupt normal cell functioning and lead to neuronal death.”
- Oxidative stress in neurodegenerative diseases (2012, background): “Oxidative stress plays a major role in AD, believed to be stronger than in other neurodegenerative diseases [74] .”
- Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis (2014, background): “Finally, in vitro studies suggest that exogenous antioxidants may reduce the toxicity of β-amyloids in the brains of AD patients [283-285].”
- Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model (2007, background): “Roles for inflammation and oxidative damage have also been implicated in neurodegeneration, and may play an important role in AD (Christen 2000; Cole et al. 2004).”
- Recent advances in Alzheimer’s disease: mechanisms, clinical trials and new drug development strategies (2024, background): “192,196 Oxidative stress presented in the early stages of AD acts as a crosstalk between different hypotheses of AD.”
- Phenolic compounds, carotenoids, and antioxidant capacities of a thermo-tolerant Scenedesmus sp. (Chlorophyta) extracted with different solvents (2019, neutral): “…as well as exposure to oxidative stress is attributed to many chronic degenerative disease and conditions in humans including cardiovascular disease, cancer, and aging-related conditions such as Alzheimer’s disease (Christen 2000; Waris and Ahsan 2006; Li et al. 2007; Sugamura and Keaney Jr 2011).”
- Role of oxidative stress in Alzheimer's disease (2016, background): “The brain of patients suffering AD present a significant extent of oxidative damage associated with the abnormal marked accumulation of Aβ and the deposition of neurofibrillary tangles (48).”
- Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease. (2003, neutral): “*p the increased age-related susceptibility in a subset of 0.01, MPTP versus untreated wt; **p 0.01, MPTP-treated Tg ver- these diseases (Bartzokis et al., 1997; Zecca et al., 2001; sus wt. Christen, 2000; Thompson et al., 2001).”
- Oxidative Stress: Harms and Benefits for Human Health (2017, background): “In AD, several experimental and clinical researches showed that oxidative damage plays a pivotal role in neuron loss and progression to dementia [34].”
- Familial Occurrence of KienbockÂ’s Disease (2011, background): “When copper acts as a pro-oxidant at times, it promotes free radical damage and may contribute to the development of Alzheimer’s disease [49,50].”