Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model

By M. Garcia-Alloza, L. Borrelli, Anete Rozkalne, Bradley T. Hyman, B. Bacskai. Journal of Neurochemistry, 2007

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Curcumin and cancer: an "old-age" disease with an "age-old" solution. (2008, background): “Curcumin, when administered to mice, can bind to amyloid proteins in the brain and disrupt the existing plaque commonly seen in AD [281].”
Identification of Amyloid Plaques in Retinas from Alzheimer’s Patients and Noninvasive In Vivo Optical Imaging of Retinal Plaques in a Mouse Model (2010, neutral): “S1a–c), demonstrated a staining pattern and size of retinal Aβ plaques very similar to curcumin labeling; both dyes were reported to bind the β-pleated sheet structures of Aβ plaques (Garcia-Alloza et al., 2007; Goldstein et al., 2003).”
Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer's Disease (2008, background): “Curcumin administration has been reported to attenuate cognitive deficits, neuroinflammation, and plaque pathology in AD models (Frautschy et al., 2001; Yang et al., 2005; Garcia-Alloza et al., 2007).”
Dietary Polyphenols and Their Biological Significance (2007, background): “Curcumin could disrupt existing plaques and restore distorted neurites in an Alzheimer mouse model [84].”