Sniffing neuropeptides: a transnasal approach to the human brain

By Jan Born, T. Lange, W. Kern, G. Mcgregor, U. Bickel, H. Fehm. Nature Neuroscience, 2002

1,340 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Endocrine and Autonomic Systems, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/d3064236cc687e03d3e0fcfd52f793f93a2e6171

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Citations in the corpus

Oxytocin, vasopressin, and human social behavior. (2009, positive): “Recent neuropharmacological research has shown that neuropeptides gain access to the human brain after intranasal administration [18,41,66,129], providing a useful method for studying the central nervous effects of OT and AVP in humans [68].”
The Physiology of Moral Sentiments (2011, positive): “Peptides closely related to OT have been shown to get into cerebral spinal fluid (Born et al., 2002) and affect brain activity (Kirsch et al., 2005).”
Oxytocin Enhances Amygdala-Dependent, Socially Reinforced Learning and Emotional Empathy in Humans (2010, result): “The decision to give treatments twice rather than once was prompted both by a previous study that only confirmed elevated CSF levels of neuropeptides up to 80 min after intranasal infusion (Born et al., 2002) and by an animal study that showed CSF OT levels fall considerably by 2 h after large incre”
Intranasal delivery of biologics to the central nervous system. (2012, background): “The same study also showed IN administration of radiolabeled calcitonin gene-related peptide resulted in significantly higher levels in the CSF, cortex, and hippocampus relative to IV administration.”
Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype. (2006, background): “A significant number of compounds have been successfully delivered to the brain or CSF following intranasal administration [2,6,20,47,51,57,58,64,65] .”
Intranasal insulin improves memory in humans. (2004, background): “A route of insulin intake avoiding these peripheral side effects is the intranasal administration (Born et al., 2002).”
A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function (2010, background): “Although invasive animal work suggested a role for OT in the human brain, this claim could not be subjected to direct experimental examination (8) until nasally administered neuropeptides were shown to impact the central nervous system (9).”
Glucagon-like peptide-1 receptor is involved in learning and neuroprotection (2003, background): “We therefore investigated the potential of [Ser(2)]exendin(1–9) for systemic administration (nasal delivery in particular”
The Oxytocin Receptor: From Intracellular Signaling to Behavior. (2018, result): “However, rather inconsistent results were reported (96, 226, 704, 754), which were only consistent in the demonstration that a maximal central uptake of 0.”
Positive Social Interactions and the Human Body at Work: Linking Organizations and Physiology (2008, background): “It is rarely used to manipulate OT levels for research because of disagreement about whether intranasal OT functions in the same way as OT released naturally in the brain (for a discussion of these issues, see Born et al., 2002; Carter & Altemus, 1997; Stockhorst & Pietrowsky, 2004 ).”
Oxytocin improves "mind-reading" in humans. (2007, positive): “Neuropeptides have been shown to cross the blood– brain barrier after intranasal administration (Born et al 2002), with several studies reporting direct effects on human behavior (Heinrichs et al 2003, 2004; Kosfeld et al 2005).”
Oxytocin shapes the neural circuitry of trust and trust adaptation in humans. (2008, positive): “Recent research has shown that neuropeptides, such as vasopressin, gain access to the human brain after intranasal administration (Born et al., 2002), providing a useful method for studying the central nervous system effects of the neuropeptide oxytocin in humans (Heinrichs and Gaab, 2007).”