Cargo Recognition and Degradation by Selective Autophagy
By D. Gatica, Vikramjit Lahiri, D. Klionsky. Nature Cell Biology, 2018
943 citations recorded by the source corpus.
Macroautophagy, initially described as a non-selective nutrient recycling process, is essential for the removal of multiple cellular components. In the past three decades, selective autophagy has been characterized as a highly regulated and specific degradation pathway for removal of unwanted cytosolic components and damaged and/or superfluous organelles. Here, we discuss different types of selective autophagy, emphasizing the role of ligand receptors and scaffold proteins in providing cargo specificity, and highlight unanswered questions in the field. In this Review Article, Klionsky and co-authors discuss selective autophagy pathways that degrade unwanted cytosolic components and organelles, and how these pathways require ligand receptors and scaffold proteins for cargo specificity.
Subfields: Cell Biology, Epidemiology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/d2d669d7d5b4876901578f36e1713c647860ffe5
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Citations in the corpus
- Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy (2022, background): “During LC3 lipidation, LC3 is sheared to the soluble form LC3I as the precursor of LC3II which is a docking site covalently attaching to the membrane of phagosomes for cargo receptors.(48,56,57) The receptor binds to specific cargoes through ubiquitin labeling, which is central to the selective recr”
- Autophagy-Dependent Ferroptosis: Machinery and Regulation (2020, background): “Mechanistically, specific autophagy receptors are used for cargo recognition and degradation, and thus better fulfill the catabolic necessities of the cell in response to various types of stress, including cell death stimuli (Gatica et al., 2018).”
- Molecular mechanisms and physiological functions of mitophagy (2021, neutral): “…is generally recognized as a bulk degradation process that non-selectively transports cytoplasmic components such as nucleic acids, proteins, and organelles to lysosomes (Nakatogawa, 2020), it also acts as a selective system to mediate clearance of particular organelles (Gatica et al , 2018).”