Drug discovery: a historical perspective.

By J. Drews. Science, 2000

2,632 citations recorded by the source corpus.

Subfields: Public Health, Environmental and Occupational Health, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/d2cce0c6b98e23429d91a49dab00e767b0195b7a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Public Health, Environmental and Occupational Health

In Radiology, Nuclear Medicine and Imaging

Citations in the corpus

Intrinsically disordered proteins in human diseases: introducing the D2 concept. (2008, background): “However, attempts to develop drug molecules that block protein-protein interactions have generally been unsuccessful (17, 35).”
ChemMine. A Compound Mining Database for Chemical Genomics1 (2005, background): “In contrast to this forward strategy, reverse chemical genomics screens resemble, in their initial stage, drug discovery approaches by screening known targets (Drews, 2000).”
MolGenSurvey: A Systematic Survey in Machine Learning Models for Molecule Design (2022, background): “Designing new molecules has been a long-standing challenge in molecular science and has critical applications in many domains such as drug discovery and material design [1].”
A guide to drug discovery: Hit and lead generation: beyond high-throughput screening (2003, background): “gif" NDATA ITEM> ]> All drugs that are presently on the market are estimated to target less than 500 biomolecules, ranging from nucleic acids to enzymes, G-protein-coupled receptors (GPCRs) and ion channel”
TTD: Therapeutic Target Database (2002, background): “So far, hundreds of proteins and nucleic acids have been explored as therapeutic targets ( 1 ).”
Integration of virtual and high-throughput screening (2002, background): “A knowledge-based approach to drug discovery is further supported by the fact that the number of new drugs introduced per year has remained constant at best over the past year”
Trends in the exploitation of novel drug targets (2011, background): “These new opportunities highlight the need to gain a deeper understanding of disease processes at the molecular level for a wider range of targets, as noted in an early paper on drug target”
Mechanisms of drug combinations: interaction and network perspectives (2009, neutral): “jpg" NDATA ITEM> ]> In recent years, drug discovery efforts have primarily focused on identifying agents that modulate preselected individual target”
Drug-like properties and the causes of poor solubility and poor permeability. (2000, background): “For example, the estimated number of drug targets is only about 500 (Drews, 2000).”
Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy (2006, background): “jpg" NDATA ITEM> ]> The identification of drug targets for multifactorial diseases such as cancer is difficult despite there being (or because there are) 5,000–10,000 potential drug targets (reviewed in Ref”