Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery

By J. Mishra, C. Dent, Ridwan Tarabishi, M. Mitsnefes, Qing Ma, C. Kelly, Stacey Ruff, Kamyar Zahedi, M. Shao, Judy A. Bean and 3 more. The Lancet, 2005

2,307 citations recorded by the source corpus.

Subfields: Critical Care and Intensive Care Medicine, Nephrology

View Paper: https://www.semanticscholar.org/paper/d2b9f21b8aedd8ee9abd341138f9f68c0994d670

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Nephrology

1. V. Vaidya
2. Claudio Ronco
3. Joseph V. Bonventre
4. John A. Kellum

Citations in the corpus

• The RIFLE criteria and mortality in acute kidney injury: A systematic review. (2008, positive): “The limitations of these current criteria may be helped by the use of emerging biomarkers for AKI, such as cystatin C and neutrophil gelatinase-associated lipocalin.(25,35) These can be used to further refine the criteria, or be used in conjunction with traditional AKI markers, such as creatinine an”
• Update on mechanisms of ischemic acute kidney injury. (2006, neutral): “protein is markedly upregulated in kidney tubules very early after ischemic AKI in animals (38) and humans (190) and is rapidly excreted in the urine, where it represents a novel, sensitive, early biomarker of ischemic AKI (38,191).”
• The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins (2006, neutral): “Urine proteome analysis for disease biomarker identification has already been applied to prostate cancer [49], renal cell carcinoma [11,50], bladder cancer [51,52], urothelial carcinoma [53], renal Fanconi syndrome [19], transitional cell carcinoma [54], type 1 diabetes [55], and acute rejection of ”
• Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury. (2006, positive): “These rodent studies have been extended to humans in a recent study indicating that NGAL levels at 2 hours is a very powerful predictor of acute kidney injury in children after cardio pulmonary bypass (23).”
• Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery. (2006, neutral): “Similar results for NGAL have been published previously.(12) The diagnostic performance is the best at 12–24 h after CPB when the IL-18 biomarker levels peak in the urine.”
• Cardiorenal syndrome. (2008, neutral): “Urine and serum NGAL are early predictors of AKI both in adult and children either in cardiac surgery or patients in the intensive care unit (ICU) (40,41).”
• The Outcome of Neutrophil Gelatinase-Associated Lipocalin (NGAL)-positive Subclinical Acute Kidney Injury: A Multicenter Pooled Analysis of Prospective Studies (2011, neutral): “Previous work supports the biological plausibility of the aforementioned notion and suggests that serum creatinine is a delayed, low-sensitivity, and could be a misleading biomarker of AKI (5,7), affected by many confounding factors 22).”
• RNA silencing: Methods and protocols (2006, neutral): “This might be related to a much faster release of tubular markers in the circulation compared with creatinine, which is known to be a slow marker that is only increased after 24 h of renal injury [60].”