Update on mechanisms of ischemic acute kidney injury.

By P. Devarajan. Journal of the American Society of Nephrology, 2006

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Delayed Graft Function in the Kidney Transplant (2011, background): “Transcripts for calcium-binding protein A4 (S100A4) and matrix Gla protein (MGP) remain upregulated during the recovery phase of AKI in small animal models (29).”
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury (2013, background): “It is notable therefore that IGFBP7 and TIMP-2 are both involved with the phenomenon of G1 cell cycle arrest during the very early phases of cell injury (Figure 5) [21-24].”
Acute kidney injury and chronic kidney disease: an integrated clinical syndrome. (2012, background): “Areas that do not complete full recovery may develop into focal areas of fibrosis.(32,55,62)”
Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome (2009, background): “The events that occur during ischemiareperfusion (I/R) injury are complex and involve altered renal morphology and hemodynamics, death of epithelial and endothelial cells, and exuberant inflammation (26).”