Many sequence variants affecting diversity of adult human height
By Daniel Fannar Gudbjartsson, G. Bragi Walters, G. Thorleifsson, Hreinn Stefansson, Bjarni V. Halldórsson, Pasha Zusmanovich, P. Sulem, S. Thorlacius, A. Gylfason, S. Steinberg and 27 more. Nature Genetics, 2008
709 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/83fe889eab64531f36d5d3a47019b09200b6ebe7
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In Genetics
- M. Sorrells
- Jean-Luc Jannink
- Jian Yang
- Peter M. Visscher
- Mark J. Daly
- E. Heffner
- David Altshuler
- Bjarni J. Vilhjálmsson
In Molecular Biology
- Mark J. Daly
- David Altshuler
- Robert M. Plenge
- Jean-Luc Jannink
- Shaun Purcell
- Peter M. Visscher
- Bjarni V. Halldórsson
- Mark I. McCarthy
Citations in the corpus
- Five years of GWAS discovery. (2012, methodology): “0610(28) in the ‘Catalog of Published Genome-wide Associated Studies’ (per 16 September 2011) [20] and assessed the tissuedependency of eQTL effect across the tissues, following the same analysis and permutation procedures.”
- Estimation of effect size distribution from genome-wide association studies and implications for future discoveries (2010, neutral): “Three recent large GWASs reported 54 susceptibility loci for height from a total of 63,000 subjects of European ancestr”
- Moral Foundations Theory: The Pragmatic Validity of Moral Pluralism (2012, background): “Given that nobody can find a set of genes that, collectively, explains 5% of the variance in how tall people are (Gudbjartsson et al., 2008), what chance is there that anyone will find a set of genes that code for mental modules such as loyalty or sanctity whose expression is far more subject to cul”
- Sequence variants at the TERT- CLPTM1L locus associate with many cancer types (2009, positive): “Furthermore, we used a method where known genotypes of relatives are used to provide information on BCC cases not genotyped ( in silico genotyping) to add genotypes that are equivalent to an additional 480 BCC cases 17 .”
- Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions (2009, methodology): “We next applied GRAIL to 42 validated SNP associations to adult height in recent GWA studies”
- The nature of nurture: Effects of parental genotypes (2017, background): “Among them, those with the strongest statistical significance are age-at-first-child (AGFC) (18), high-density lipoprotein (19) (HDL), body mass index (20) (BMI), fasting glucose level (21) (FG), height (22) (HT), and cigarettes smoked per day by smokers (23) (CPD).”
- Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity (2009, background): “This may be due, in part, to the polygenic nature of obesity, whereby several sequence variants exert small effects and for which very large number of samples are required for detection, such as is the case with sequence variants affecting diversity in normal human heigh”
- Genomic Selection Accuracy using Multifamily Prediction Models in a Wheat Breeding Program (2011, background): “Despite a high h2 (~0.80) and a TP of tens of thousands of individuals, only ~5% of the phenotypic variance for human height has been accounted for with ~50 signifi - cant markers (Gudbjartsson et al., 2008; Lettre et al., 2008; Weedon et al., 2008; Visscher, 2008).”