Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
By G. Thorleifsson, G. Bragi Walters, Daniel Fannar Gudbjartsson, V. Steinthorsdottir, P. Sulem, A. Helgadóttir, U. Styrkársdóttir, S. Gretarsdottir, S. Thorlacius, I. Jónsdóttir and 25 more. Nature Genetics, 2009
1,410 citations recorded by the source corpus.
Subfields: Genetics
View Paper: https://www.semanticscholar.org/paper/1275b5732ae73132ca55283a337a34eaae7b9a62
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Citations in the corpus
- Reward, dopamine and the control of food intake: implications for obesity (2010, neutral): “Although genetic studies have revealed point mutations that are over-represented among obese individuals [4], for the most part, obesity is thought to be under polygenic control [6,7].”
- Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits (2011, methodology): “The variation in CT hepatic steatosis explained by the tested SNPs was estimated from stage 2 analyses using 2f (1 – f) a(2), where f is the frequency of the variant and a is its additive effect in units of standard deviations from the meta analysis [48].”
- Genome-partitioning of genetic variation for complex traits using common SNPs (2011, positive): “0%) of variances for BMI, vWF and QTi, respectively, can be explained by all the autosomal SNPs, which is approximately tenfold, twofold and threefold larger than the variance explained by all known validated loci found by GWAS for BM”
- MultiPhen: Joint Model of Multiple Phenotypes Can Increase Discovery in GWAS (2012, background): “There have been many more genetic determinants of Body-mass-index (BMI), defined as the ratio of weight to height squared, discovered than those of weight [4], and the significance of rs8050136 in FTO was reported to be 11 orders of magnitude more significant for BMI than weight [5].”
- Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts (2013, background): “[24] and previously published genome-wide association studies for obesity-related traits [23,25,26].”