Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model

By S. Sano, K. Chan, Steve Carbajal, J. Clifford, M. Peavey, K. Kiguchi, S. Itami, B. Nickoloff, J. DiGiovanni. Nature Medicine, 2005

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MicroRNAs: Novel Regulators Involved in the Pathogenesis of Psoriasis? (2007, background): “In psoriasis, there is evidence for the pathogenic relevance of several different cell types that normally occur in skin: keratinocytes [12], fibroblasts [13], monocyte-derived immunocytes [11,14], T cells [15], and mast cells [16].”
Mechanisms of cutaneous toxicities to EGFR inhibitors (2006, background): “Indeed, mice with a constitutively active STAT3 in the basal layer have a phenotype that is similar to psoriasi”
Skin immune sentinels in health and disease (2009, background): “Furthermore, mice with constitutive activation of the transcription factor signal transducer and activator of transcription 3 (STAT3), which is downstream of cytokine receptors such as the IL-23 receptor, in keratinocytes developed a psoriasis-like conditio”