The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer.

By W. Naugler, M. Karin. Trends in Molecular Medicine, 2008

742 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/d24290cf4b416aae0c7f50a5b9f41a3f3382fc86

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Robert F. Schwabe
2. A. Sica
3. A. Mantovani
4. F. Greten
5. F. Balkwill

In Immunology

1. A. Mantovani
2. A. Sica
3. P. Allavena
4. C. Garlanda
5. F. Balkwill
6. F. Colotta
7. F. Greten
8. Tom Luedde

In Oncology

1. A. Mantovani
2. A. Sica
3. P. Allavena
4. C. Garlanda
5. F. Balkwill
6. M. Karin
7. F. Greten
8. F. Colotta

Citations in the corpus

• Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells (2009, background): “The role of cytokines in cancer has been well studied (Massague, 2008; Naugler and Karin, 2008), particularly in breast cancer (Nicolini et al.”
• gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. (2009, background): “…with aberrant Stat3 activation during metaplastic transformation (Ernst et al., 2008; Miyatsuka et al., 2006) and in cancers of epithelial origin, the IL-6 family cytokines have recently been proposed to provide one of the missing links between inflammation and cancer (Naugler and Karin, 2008).”
• Research Progress on the Relationship between Atherosclerosis and Inflammation (2018, background): “Interleukin-6 is produced by macrophages and T cells during the early stage of the immune response and inflammation, and has proinflammatory properties [80].”
• The effects of acute psychological stress on circulating and stimulated inflammatory markers: A systematic review and meta-analysis (2017, background): “…disease (CVD; Pearson et al., 2003), as well as accelerated progression of diseases that involve inflammatory pathophysiology (e.g. cancer, HIV, asthma, and rheumatoid arthritis (Choy, 2012; Deeks et al., 2013; Elinav et al., 2013; Fu et al., 2013; McInnes & Schett, 2011; Naugler & Karin, 2008).”
• Obesity and Cancer: The Role of Dysfunctional Adipose Tissue (2009, background): “Cancer Epidemiol Biomarkers Pre that this essential cytokine is associated with several disease processes, including chronic inflammatory diseases and cancer (125).”
• Oxidative Stress in Obesity: A Critical Component in Human Diseases (2014, background): “, adipocytes, endothelial cells, β-pancreatic cells, macrophages, and monocytes), regulates energy homeostasis and inflammation, influencing the transition from acute to chronic inflammatory disease, such as obesity and insulin resistance [14], by promoting the synthesis of pro-inflammatory cytokine”
• Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550) (2011, background): “In addition to promoting Th17 differentiation, it regulates immune responses, the acute phase reaction, hematopoiesis, and bone metabolism (73, 74).”
• Cancer-related inflammation: common themes and therapeutic opportunities. (2012, background): “Via STAT3, genes that promote cell proliferation and angiogenesis are induced in the tumor microenvironment by IL-6 [43].”
• The Two Faces of IL-6 in the Tumor Microenvironment (2014, background): “Acting through STAT3, IL-6 also supports tumor cell survival by inducing the expression of anti-apoptotic proteins including bcl2, bcl-XL and survivin [5,20,33,39].”
• A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses (2009, neutral): “How NF-κB–induced inflammatory processes drive carcinogenesis is unclear, although IL-6 seems to be pivota”
• Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. (2009, background): “A major effector molecule of NF-kB activation and also linked to STAT3 is IL-6, a multifunctional cytokine with growth-promoting and anti-apoptotic activity [28,29].”
• Targeting interleukin-6 in inflammatory autoimmune diseases and cancers. (2014, background): “During acute inflammation, monocytes and macrophages are the main producers of IL-6 after activation of Toll-like receptors (TLRs) via a MyD88-dependent pathway, whereas T cells appear to be the major source of IL-6 during chronic inflammation (Naugler & Karin, 2008).”
• NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma (2011, background): “In addition, NF-κB target genes, such as IL6 , activate additional cell signaling pathways including Stat3, which exerts a crucial role in inflammation, wound healing and hepatocarcinogenesis, and may be an essential link between inflammation and cancer”