Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease
By S. Seshadri, A. Beiser, J. Selhub, P. Jacques, I. Rosenberg, Ralph B. D’Agostino, Peter W. F. Wilson, P. Wolf. 2002
3,216 citations recorded by the source corpus.
Subfields: Nutrition and Dietetics, Physiology, Rheumatology
View Paper: https://www.semanticscholar.org/paper/d23761c41d0f795c15e71032cf81e6d9e7f3ea91
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In Nutrition and Dietetics
In Physiology
In Rheumatology
Citations in the corpus
- B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review (2016, background): “The “homocysteine hypothesis” originally stemmed from the observation that increased fasting plasma levels of the potentially toxic amino acid homocysteine were an independent predictor of cardiovascular disease [60,61],with this observation subsequently extended to cognitive function [62], Alzheime”
- Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis (2014, background): “Accordingly, a potential influence of hyperhomocysteinemia on cognitive functioning among older adults was postulated and several studies were able to associate high levels of Hcy with increased risk of incident AD or all-cause dementia [206,217,224,228,233,234].”
- The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. (2004, background): “The remaining 70–80% of Alzheimer’s disease have the same pathological findings of amyloid plaques, phosphorylated microtubular proteins and loss of hippocampal neurons associated with memory loss and increasing dementia, but from causes which include ischemia [64] mild trauma [65] elevated plasma h”
- Facts and recommendations about total homocysteine determinations: an expert opinion. (2004, background): “A large prospective study showed that increased tHcy up to 11 years before the diagnosis of dementia is associated with twice the risk of Alzheimer disease (196).”
- Folates in plants: biosynthesis, distribution, and enhancement (2006, background): “Increased plasmaHcy content may also be a risk factor for different forms of dementia including Alzheimer’s disease (Seshadri et al. 2002).”
- Genetic diversity of folate profiles in seeds of common bean, lentil, chickpea and pea (2015, background): “It is also associated with numerous neurodegenerative disorders, including Alzheimer’s disease (Seshadri et al., 2002), and various cancers (Choi and Friso, 2005).”
- Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study. (2006, methodology): “Total plasma homocysteine concentrations were determined with the use of high-performance liquid chromatography with fluorometric detection.(4) The coefficient of variation for this assay was 9%.”
- Aggregation of vascular risk factors and risk of incident Alzheimer disease (2005, background): “Diabetes (6–8), hyperlipidemia (9), hypertension (10), heart disease (11), smoking (12,13), homocysteine (14), and obesity (15) are associated with a higher risk of AD.”