The receptors and coding logic for bitter taste

By K. L. Mueller, M. Hoon, Isolde Erlenbach, Jayaram Chandrashekar, C. Zuker, N. Ryba. Nature, 2005

506 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Nutrition and Dietetics, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/d233713343f017e7c9edcd85a797f70cb1a5e6d4

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In Biomedical Engineering

In Nutrition and Dietetics

In Sensory Systems

Citations in the corpus

The molecular receptive ranges of human TAS2R bitter taste receptors. (2010, background): “T2R) gene family encoding bitter taste receptor candidates (Adler et al. 2000; Chandrashekar et al. 2000; Matsunami et al. 2000; Mueller et al. 2005; Behrens et al. 2007).”
Common Sense about Taste: From Mammals to Insects (2009, background): “On the other, introduction of novel T2Rs expands the bitter taste repertoire (Mueller et al., 2005).”
The receptors and cells for mammalian taste (2006, background): “On the one hand, animals lacking a specific T2R (for example, T2R5, the candidate cycloheximide receptor), exhibited a marked and selective loss of their ability to taste the cognate bitter compoun”
Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “PLC 2 / mice are also impaired in sweet, amino acid, and bitter taste reception (1091, 1808).”
What is it like to be a rat? Rat sensory perception and its implications for experimental design and rat welfare (2008, background): “Their bitterness thresholds for some compounds differ from ours (Glendinning, 1994; Mueller et al., 2005), allowing denatonium benzoate – which tastes less bitter to rats than to humans and some other animals – to be added to baits to prevent its consumption by non-target species”
Cellular and Molecular Mechanisms of Pain (2009, unknown): “…where exchanging a sweet receptor for a bitter one in a population of “sweet taste afferents” does not alter the behavior provoked by activity in that labeled line; under these conditions, a bitter tastant stimulates these afferents to elicit a perception of sweetness (Mueller et al., 2005).”
The cell biology of taste (2010, background): “on the results of replacing a modified opioid receptor for the bitter or sweet receptors in taste cells (Zhao et al., 2003; Mueller et al., 2005).”
Chemosensation in C. elegans. (2006, result): “Similar results have been obtained in the mammalian sweet and bitter taste systems, suggesting that hard-wired sensory maps define intrinsic chemosensory preferences in many animals (Mueller et al., 2005).”