TimeTree: a public knowledge-base of divergence times among organisms

By S. Blair Hedges, Joel T. Dudley, Sudhir Kumar. Bioinform., 2006

1,236 citations recorded by the source corpus.

Subfields: Ecology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d2167c06eaa23893331ab0ae062e57ce22b89e29

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Ecology

1. Sudhir Kumar
2. Michael Suleski
3. Glen Stecher
4. Haiming Tang
5. Paul D. Thomas
6. J. Earl
7. H. Whiteman
8. Jussi Taipale

In Genetics

1. Glen Stecher
2. Sudhir Kumar
3. Michael Suleski
4. Paul D. Thomas
5. Haiming Tang
6. S. Blair Hedges
7. Maxwell D. Sanderford
8. J. Earl

In Molecular Biology

1. Glen Stecher
2. Sudhir Kumar
3. Michael Suleski
4. Haiming Tang
5. Paul D. Thomas
6. S. Blair Hedges
7. Alan J. Filipski
8. Maxwell D. Sanderford

Citations in the corpus

• Conservation of transcription factor binding specificities across 600 million years of bilateria evolution (2015, background): “It is estimated that the divergence between vertebrate and invertebrate lineages occurred over 600 million years ago (Hedges et al., 2006; Peterson et al., 2008).”
• Allosteric Disulfide Bonds (2006, background): “sapiens half-cystines, cysteines, tryptophan, and all amino acids against orthologous proteins in other species of Metazoan and Fungi as a function of the time of the last common ancestor (Million Years Ago, MYA) (Hedges et al. 2006).”
• Positional conservation and amino acids shape the correct diagnosis and population frequencies of benign and damaging personal amino acid mutations. (2009, methodology): “Species divergence times were obtained from an advanced version of the TimeTree resource (www.timetree.org, version 2.0 prerelease) (Hedges et al. 2006).”
• Ancient Protostome Origin of Chemosensory Ionotropic Glutamate Receptors and the Evolution of Insect Taste and Olfaction (2010, background): “First, we have shown that the IRs were very likely to have been present in the last common ancestor of Protostomia, an estimated 550–850 million years ago [20].”
• PANTHER-PSEP: predicting disease-causing genetic variants using position-specific evolutionary preservation (2016, methodology): “Because PANTHER trees are reconciled with the known species tree, we can use best estimates of speciation times (Hedges et al. , 2006) to date the ancestral preservation of each site.”
• TimeTree 5: An Expanded Resource for Species Divergence Times (2022, methodology): “The TimeTree of Life (TToL) resource has been delivering scientific knowledge about species 2 divergence times inferred from the analysis of molecular sequences (Hedges et al. 2006; Kumar 3 and Hedges 2011; Kumar et al. 2017).”