The Mouse Genome Database (MGD): facilitating mouse as a model for human biology and disease

By Janan T. Eppig, Judith A. Blake, Carol J. Bult, J. Kadin, J. Richardson. 2014

385 citations recorded by the source corpus.

The Mouse Genome Database (MGD, http://www.informatics.jax.org) serves the international biomedical research community as the central resource for integrated genomic, genetic and biological data on the laboratory mouse. To facilitate use of mouse as a model in translational studies, MGD maintains a core of high-quality curated data and integrates experimentally and computationally generated data sets. MGD maintains a unified catalog of genes and genome features, including functional RNAs, QTL and phenotypic loci. MGD curates and provides functional and phenotype annotations for mouse genes using the Gene Ontology and Mammalian Phenotype Ontology. MGD integrates phenotype data and associates mouse genotypes to human diseases, providing critical mouse–human relationships and access to repositories holding mouse models. MGD is the authoritative source of nomenclature for genes, genome features, alleles and strains following guidelines of the International Committee on Standardized Genetic Nomenclature for Mice. A new addition to MGD, the Human–Mouse: Disease Connection, allows users to explore gene–phenotype–disease relationships between human and mouse. MGD has also updated search paradigms for phenotypic allele attributes, incorporated incidental mutation data, added a module for display and exploration of genes and microRNA interactions and adopted the JBrowse genome browser. MGD resources are freely available to the scientific community.

Subfields: Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Mapping Sub-Second Structure in Mouse Behavior. (2015, background): “Furthermore, heterozygous mice—which have no reported phenotype (André et al., 1998; Eppig et al., 2015; Liu et al., 2013; Masana et al., 2007), exhibit wild-type running wheel behavior (Masana et al.”
Mouse Genome Database (MGD)-2018: knowledgebase for the laboratory mouse (2017, methodology): “org/batch) (21) is used for retrieving bulk data about lists of genome features.”
Ensembl core software resources: storage and programmatic access for DNA sequence and genome annotation (2016, background): “If a species has a nomenclature committee such as HGNC or MGI (37) these links will take the highest priority.”
DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants (2016, background): “- The Comparative Toxicogenomics Database (CTD) that provides information about chemicals and genes, and their effect in human health and disease (3) - UniProt, a repository centred on protein sequence and function, that also include disease annotations from OMIM, and from expert curation of the sci”
Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity (2017, neutral): “The experiments were not randomized and the investigators were not blinded to allocation during experiments and outcome assessment.”
BiGG Models: A platform for integrating, standardizing and sharing genome-scale models (2015, background): “Similar databases are available for model organisms such as yeast (5) and mouse (6).”