Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
By Yuval Dor, Juliana R. Brown, O. I. Martinez, D. Melton. Nature, 2004
1,418 citations recorded by the source corpus.
Subfields: Endocrinology, Diabetes and Metabolism, Genetics, Surgery
View Paper: https://www.semanticscholar.org/paper/d17b0c35ccf5ba102ffbe8127f6e29257aecf96b
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Endocrinology, Diabetes and Metabolism
In Genetics
In Surgery
Citations in the corpus
- Genetics and biology of pancreatic ductal adenocarcinoma. (2006, background): “Despite extensive investigation, such cells have not been isolated, and it appears that the majority of cells in vivo are generated by replication of existing cells rather than formation of new cells from stem cells (Dor et al. 2004).”
- Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells. (2011, methodology): “Both labeling approaches are based on the Cre/lox system, routinely used in transgenic animals (Dor et al., 2004).”
- Origin of new glial cells in intact and injured adult spinal cord. (2010, result): “However, several previous studies support that the response of a tissue to an injury may differ from simply modulating the activity of the stem or progenitor cells that maintain homeostasis in the intact tissue (Dor et al., 2004; Dor and Melton, 2008; Ito et al., 2005; Levy et al., 2005; Nakagawa et”
- Epithelial stem cells: turning over new leaves. (2007, positive): “A similar mode of regeneration called self-duplication has also been proposed to account for the renewal of pancreatic islet cells (Dor et al., 2004).”
- Beta Cell Dysfunction and Insulin Resistance (2013, background): “In healthy adult mice, and in mice recovering from a diabetogenic injury, new beta cells are derived mainly by replication of preexisting beta cells (Dor et al., 2004; Georgia and Bhushan, 2004; Frontiers in Endocrinology | Diabetes March 2013 | Volume 4 | Article 37 | 4 Brennand et al., 2007; Nir…”