Mitochondrial Dysfunction and Type 2 Diabetes

By Bradford B. Lowell, Gerald I. Shulman. Science, 2005

1,143 citations recorded by the source corpus.

Subfields: Epidemiology, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/d14f05c63267fe5a2addd07889007ae0ace1ad92

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Jun Yoshino
2. M. Abdollahi
3. Jianping Ye
4. S. Mostafalou
5. S. Imai

In Physiology

1. S. Imai
2. Jun Yoshino
3. Jianping Ye

In Surgery

1. Jianping Ye

Citations in the corpus

• Pesticides and human chronic diseases: evidences, mechanisms, and perspectives. (2013, background): “Abnormal function of the mitochondrial respiratory chain is the primary cause of imbalanced cellular energy homeostasis and has been widely studied in different types of human diseases most of all diabetes (Abdul-Ghani and DeFronzo, 2008; Kim et al., 2008; Lowell and Shulman, 2005; Ma et al., 2012) ”
• Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice (2011, background): “, SIRT3–5) might be affected by deficits in NAMPT-mediated NAD biosynthesis, potentially resulting in the mitochondrial dysfunction observed in T2D (Lowell and Shulman, 2005).”
• Mechanisms of insulin resistance in obesity (2013, background): “of fp ri nt of fatty acid and glucose, a reduction in mitochondrial function may contribute to FFA and lipid accumulation in favor of insulin resistance [54].”