Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3.

By Rashu B. Seth, Lijun Sun, Chee-Kwee Ea, Zhijian J. Chen. Cell, 2005

1,897 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/d1088cc9e4c936b7f33dbf165f316ce45dda197b

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Lijun Sun
Yasuo Tanaka
Xin Cai
Y. Chiu
Siqi Liu
Zhijian J. Chen
D. Kolakofsky
F. Hou

Citations in the corpus

The specific and essential role of MAVS in antiviral innate immune responses. (2006, methodology): “The adaptor protein that links RIG-I to IKK and TBK1/ IKK3 activation is the recently identified MAVS (Seth et al., 2005), also known as IPS-1 (Kawai et al., 2005), VISA (Xu et al., 2005), or CARDIF (Meylan et al., 2005).”
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation (2015, methodology): “The rabbit antibodies against human MAVS and STING were generated as described before (24, 35).”
RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. (2009, background): “Although the DNA-binding protein DAI (ZBP1) has been proposed as a DNA sensor that induces type I IFNs, DAI-deficient mice and cells from these mice do not have apparent defects in producing type I IFNs in response to DNA stimulation (Ishii et al., 2008; Takaoka et al., 2007).”
Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High Affinity Ligand for STING (2013, unknown): “MAVS, an essential adaptor protein of the RIG-I pathway (Seth et al., 2005), was able to induce IFNb in all of these cell lines.”
Type I interferon inhibits interleukin-1 production and inflammasome activation. (2011, background): “This gives rise to anefficient interaction with MAVS/VISA/IPS-1/Cardif, a crucial downstream adaptor protein (Kawai et al., 2005; Meylan et al., 2005; Seth et al., 2005; Xu et al., 2005), leading to the recruitment of signaling molecules such as the TBK1 complex to MAVS.”