Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

By Siqi Liu, Xin Cai, Jiaxi Wu, Qian Cong, Xiang Chen, Tuo Li, Fenghe Du, Junyao Ren, Youtong Wu, Nick V. Grishin and 1 more. Science, 2015

1,776 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/45c7b74a5324341509437c3b931caad4eba6617f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Tuo Li
2. Zhijian J. Chen
3. A. Ablasser
4. V. Deretic
5. Shizuo Akira
6. N. Perkins
7. G. Barber
8. Ivan Dikic

In Molecular Biology

1. Zhijian J. Chen
2. A. Ablasser
3. Tuo Li
4. V. Deretic

Citations in the corpus

• The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer (2018, background): “This process is thought to liberate the STI NG carboxyl terminus to subsequently recruit and activate TANK-binding kinase 1 (TBK1) and IFN regulatory factor 3 (IRF3) via a phosphorylationdependent mechanism (Tanaka and Chen, 2012; Liu et al., 2015).”
• Evasion of Type I Interferon by SARS-CoV-2 (2020, background): “The phosphorylated IRF3 forms a dimer and translocates to the nucleus, activating the transcription of type I IFN (IFN-I) genes (Fitzgerald et al., 2003; Liu et al., 2015).”
• Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways (2015, neutral): “TBK1 also phosphorylates and activates the transcription factor IRF3 (40–42) and the critical innate immunity signaling componentsMAVSandSTING (43).”