AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

By R. Medema, G. Kops, J. Bos, B. Burgering. Nature, 2000

1,560 citations recorded by the source corpus.

Subfields: Aging, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d10540c2a7755e645759066022b1431456ac2e58

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. A. Brunet
2. B. Burgering
3. M. McBurney
4. W. Gu
5. M. Lemieux
6. Maria Carla Motta
7. E. L. Greer
8. L. Guarente

In Molecular Biology

1. A. Brunet
2. W. Gu
3. D. Accili
4. L. Guarente
5. B. Burgering
6. E. L. Greer
7. Dervis A M Salih
8. J. Kruse

Citations in the corpus

• Malignant astrocytic glioma: genetics, biology, and paths to treatment. (2007, background): “…their exclusion from the nucleus, reduces the expression of a number of important target genes, including the CDK inhibitors p21 WAF1/CIP1 and p27 KIP1 (both of which are also directly targeted by Akt) and the RB family member p130 (Medema et al. 2000; Kops et al. 2002; Seoane et al. 2004).”
• Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies. (2016, background): “are known to cause overexpression of CDK inhibitor p27,whereas cyclin D1 and D2 were repressed [97, 98].”
• FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. (2007, neutral): “…T cell lymphoma suppressor gene (Geisen et al., 2003; Kang-Decker et al., 2004; Martins and Berns, 2002) and FoxO target (Dijkers et al., 2000; Medema et al., 2000; Stahl et al., 2002), was identified as one of the most significantly downregulated genes with a high number of evolutionarily…”
• Cell Cycle Inhibition by FoxO Forkhead Transcription Factors Involves Downregulation of Cyclin D (2002, background): “thesis rates upon FoxO4 expression (33), indicating that DAF-”
• FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK (2004, result): “Similar results were obtained using the 6xDBE or p27 promoter constructs, both of which are FOXO responsive The EMBO Journal VOL 23 | NO 24 | 2004 &2004 European Molecular Biology Organization4804 promoters (Furuyama et al, 2000; Medema et al, 2000; data not shown).”
• Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action. (2002, background): “By phosphorylating Forkhead transcription factors, it can inhibit AFX-mediated transcription of p27 (72).”