Untargeted large-scale plant metabolomics using liquid chromatography coupled to mass spectrometry

By R. D. Vos, S. Moco, A. Lommen, J. Keurentjes, R. Bino, R. Hall. Nature Protocols, 2007

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Metabolomics for functional genomics, systems biology, and biotechnology. (2010, methodology): “Targeted flavonoid analysis by LC-MS and nontargeted metabolome analysis by FT-MS in combination with the transcriptome led to the prediction of the involvement of upregulated genes in the pathway.”
Producing more with less: Strategies and novel technologies for plant-based food biofortification (2013, background): “Plants are very rich in chemically diverse metabolites, which are usually present in a large range of concentrations (De Vos et al., 2007), and no single analytical method is currently capable of extracting and detecting all metabolites.”