The Increasing Complexity of the Cancer Stem Cell Paradigm

By Jeffrey M. Rosen, C. Jordan. Science, 2009

728 citations recorded by the source corpus.

The investigation and study of cancer stem cells (CSCs) have received enormous attention over the past 5 to 10 years but remain topics of considerable controversy. Opinions about the validity of the CSC hypothesis, the biological properties of CSCs, and the relevance of CSCs to cancer therapy differ widely. In the following commentary, we discuss the nature of the debate, the parameters by which CSCs can or cannot be defined, and the identification of new potential therapeutic targets elucidated by considering cancer as a problem in stem cell biology.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/d0fac21136362b9778a1f88fcf6210f37ddd76b2

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Citations in the corpus

Spherical Cancer Models in Tumor Biology (2015, background): “Moreover, the concept of CSC itself remains subject to debate [154], and the difference between the CSC, cancer-initiating cells, and highly proliferating cells is ambiguous.”
Stem cell gene expression programs influence clinical outcome in human leukemia (2011, background): “First, the firm linkage between LSC and HSC signatures and the ability of these signatures to predict survival provides evidence for the hierarchical organization of AML according to the CSC model and suggests that LSCs are not artifacts of experimental xenograft model”
Targeting mitochondria for cancer therapy (2010, background): “This might be particularly interesting as cancer stem cells are thought to have the capacity to repopulate the tumour and are refractory to conventional therapeutic approache”
Deconstructing the molecular portraits of breast cancer (2010, background): “…of a normal stem/progenitor cell with the inherent capacity to self-renew and to differentiate into the various cell types that form the bulk of the tumor, or alternatively, arises from a differentiated cancer cell that acquires the ability to self-renew (Rosen and Jordan, 2009; Jordan, 2009).”
Macrophages in Tumor Microenvironments and the Progression of Tumors (2012, background): “However, stromal cells, such as fibroblasts and immune cells, are also known to play important roles in tumor progression [97].”