Dynamics of the p53-Mdm2 feedback loop in individual cells
By Galit Lahav, N. Rosenfeld, Alex Sigal, N. Geva-Zatorsky, Arnold J. Levine, Michael B. Elowitz, Uri Alon. Nature Genetics, 2004
1,069 citations recorded by the source corpus.
Subfields: Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/d0f7b9e61ac1c0c4be4fa4b22470673f006eb313
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- Aviv Regev
- Nir Friedman
- Eran Segal
- James J. Collins
- Daphne Koller
- Moshe Oren
- Timothy C. Elston
- Arnold J. Levine
In Oncology
- Moshe Oren
- Arnold J. Levine
- Jeremy E. Purvis
- Galit Lahav
- James J. Collins
- Y. Yarden
- R. Avraham
- Carol Prives
Citations in the corpus
- An Integrated Mechanistic Model of Pan-Cancer Driver Pathways Predicts Stochastic Proliferation and Death (2017, methodology): “We specified ultrasensitive activation of ATM and ATR by DNA damage and tuned DNA repair activities (properties hypothesized by (Lahav et al., 2004)) to ensure our model recapitulated these features (Fig.”
- Single-Cell and Single-Molecule Analysis of Gene Expression Regulation (2016, background): “The number of pulses varies among cells and the mean of pulses increases with DNA damage, but the individual pulses are of fixed duration and amplitude (77).”
- Feedback regulation of EGFR signalling: decision making by early and delayed loops (2011, background): “For example, pulsed responses of p53 to radiation became evident only when analysed at single-cell resolutio”
- Stochasticity in gene expression: from theories to phenotypes (2005, background): “Examples of delay-driven genetic oscillations include the DNA-damage response that is mediated by the P53–MDM2 FEEDBACK LOOP”
- Transcriptional pulsing of a developmental gene. (2006, background): “The pulses are considerably slower than the oscillations in p53 protein levels (mean duration 5 hr), which occur after DNA damage [6].”
- The p53 protein and its molecular network: modelling a missing link between DNA damage and cell fate. (2014, background): “, themodel quickly produces sustained (undamped) oscillations [14,17].”
- The Hes gene family: repressors and oscillators that orchestrate embryogenesis (2007, background): “Furthermore, recent studies have revealed that, other than the circadian clock genes, Hes genes are not the only oscillators (Nelson et al., 2004; Lahav et al., 2004).”
- The first 30 years of p53: growing ever more complex (2009, positive): “Not surprisingly, the MDM2–p53 loop has caught the attention of many systems biologists and computational biologists and has since become a favourite model for regulatory interactions within a pathway (for example, see Ref”