Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor

By M. Smith, Tanya Yatsunenko, M. Manary, Indi Trehan, R. Mkakosya, Jiye Cheng, A. Kau, S. Rich, P. Concannon, J. Mychaleckyj and 9 more. Science, 2013

1,092 citations recorded by the source corpus.

Subfields: Molecular Biology, Nutrition and Dietetics, Physiology

View Paper: https://www.semanticscholar.org/paper/d0c2780444eef558fd2c4ebc1c88e8b29526b1fc

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Citations in the corpus

Advancing our understanding of the human microbiome using QIIME (2013, background): “…because certain phenotypes can be transmitted by transmitting the microbiota (Carvalho et al., 2012; McLean, Bergonzelli, Collins, & Bercik, 2012; Turnbaugh et al., 2009), even including transmission of human phenotypes into mice (Diaz Heijtz et al., 2011; Koren et al., 2012; Smith et al., 2013).”
The gut microbiota mediates the anti-seizure effects of the ketogenic diet (2018, neutral): “Several diet-induced host pathologies are mediated by changes in the gut microbiota in mouse models, including symptoms of atherosclerosis in response to the carnitine-rich diet, undernutrition in response to the Malawian diet, and abnormal social behavior in response to maternal high-fat diet (Buff”
The Immune System in Children with Malnutrition—A Systematic Review (2014, background): “A twin study from Malawi suggested that micro-flora pattern could also play a role in developing malnutrition [76].”
The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation (2016, background): “Dysbiosis of the microbiome has been associated with a large number of health problems and causally implicated in metabolic, immunological, and developmental disorders, as well as susceptibility to development of infectious diseases [4–11].”
Human gut microbiota in health and disease: Unveiling the relationship (2022, background): “Furthermore, a study found that gut microbiota contributes a beneficial impact to the start of severe malnutrition, which can be regenerated by microbiota transplantation into gnotobiotic mice (Smith et al., 2013).”
The stunting syndrome in developing countries (2014, background): “177 Kwashiorkor was characterised by a functionally immature microbiome, which matured during therapeutic feeding (with enrichment of potentially beneﬁcial organisms, such as Biﬁdobacteria and Lactobacillus) but was not sustained once therapeutic feeding was stopped.”
Conducting a Microbiome Study (2014, background): “In studies that do not include a time series, the best-matched controls are monozygotic twins, in which genotype is constant within twin pairs: for instance, the effect of obesity on the microbiome has been studied in monozygotic co-twins discordant for this phenotype (Smith et al., 2013).”
Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation (2015, background): “…intestinal microbes contribute to the regulation of energy homeosta- 228 Cell Metabolism 22, 228–238, August 4, 2015 ª2015 The Author sis and fat storage and may play a role in obesity and its complications (Karlsson et al., 2013; Qin et al., 2012; Smith et al., 2013; Tremaroli and Bäckhed, 2012).”