Notch signaling controls multiple steps of pancreatic differentiation

By L. C. Murtaugh, B. Stanger, K. Kwan, D. Melton. Proceedings of the National Academy of Sciences of the United States of America, 2003

826 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/d09f354bce0bbd18ab066a10490a3583700baeea

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. M. Fortini
2. R. DePinho

In Molecular Biology

1. Alec C. Kimmelman
2. N. Bardeesy
3. M. Fortini
4. T. Ohtsuka
5. C. Wright
6. F. C. Pan
7. R. DePinho
8. D. Melton

In Surgery

1. M. Fortini
2. C. Wright
3. F. C. Pan
4. D. Melton
5. Alec C. Kimmelman

Citations in the corpus

• Notch signaling: the core pathway and its posttranslational regulation. (2009, methodology): “For example, in the Drosophila retina and mouse pancreas, Notch signaling is used reiteratively to generate a spatially intermingled pattern of cells with distinct structural and physiological roles (Cagan and Ready, 1989; Murtaugh et al., 2003).”
• Genetics and biology of pancreatic ductal adenocarcinoma. (2006, background): “1999; Jensen et al. 2000; Moshous et al. 2001; Hald et al. 2003; Murtaugh et al. 2003).”
• Mathematical Modelling of Molecular Pathways Enabling Tumour Cell Invasion and Migration (2015, methodology): “In our previous work, this specific double mutation NICD GoF/p53 LoF has been carried out experimentally in a mouse model, by crossing the villin-CreERT2mice [129] (in this study referred as p53 LoF) and RosaN1icmice [130] (in this study referred as NICD GoF) with the isogenic C57BL/6 animals to gen”
• Generation of functional human pancreatic β cells in vitro (2014, methodology): “…organisms (Gamer and Wright, 1995; Henry and Melton, 1998; Ninomiya et al., 1999; Apelqvist et al., 1999; Kim et al., 2000; Hebrok et al., 2000; Murtaugh et al., 2003) identified genes and signals important for the pancreatic lineage, and these have been effectively used to form cells in the b…”
• The Hes gene family: repressors and oscillators that orchestrate embryogenesis (2007, background): “…cell NICD Cytoplasm Nucleus OFF ON Delta (ligand) Notch (receptor) S3 cleavage S2 cleavage D E V E LO P M E N T 1247PRIMERDevelopment 134 (7) cell differentiation by antagonizing Ptf1a function (Hald et al., 2003; Murtaugh et al., 2003; Esni et al., 2004; Fujikura et al., 2006).”
• Pancreas organogenesis: From bud to plexus to gland (2011, background): “…Domain (N1ICD) over the Pdx1þ endoderm have greatly impaired endocrine and exocrine differentiation, and the hypoplastic pancreatic epithelium is effectively trapped in the undifferentiated state appropriate to when the NICD expression is activated (Hald et al., 2003; Murtaugh et al., 2003).”