Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways

By H. Björkbacka, V. Kunjathoor, K. Moore, Stephanie L Koehn, C. M. Ordija, Melinda A Lee, T. Means, Kristen A. Halmen, A. Luster, D. Golenbock and 1 more. Nature Medicine, 2004

693 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/d08a6a44081eebfff50062db5a996c190d8c91cb

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In Immunology

1. P. Noble
2. R. Stocker
3. D. Golenbock
4. K. Moore
5. L. Stuart
6. Jiurong Liang
7. A. Tedgui
8. Z. Mallat

Citations in the corpus

• NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases (2015, neutral): “…. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 302 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 304”
• Role of oxidative modifications in atherosclerosis. (2004, background): “In addition, there is now evidence that hypercholesterolemia promotes atherosclerosis lesion development by activating macrophage innate immunity signaling pathways (63), thereby directly linking elevated serum lipids to a pro-inflammatory signaling cascade.”
• CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer (2009, background): “We therefore tested whether fibrillar β-amyloid peptide (1-42) (Aβ1-42) could activate TLR4-TLR6 signaling via CD36.”
• Cytokines in atherosclerosis: pathogenic and regulatory pathways. (2006, result): “Two lines of evidence support this hypothesis: 1) oxLDL enhances TLR4 expression in macrophages (760), and 2) TLR4 or its intracellular adaptor protein, MyD88, reduces atherosclerosis in uninfected apoE-deficient mice, concomitant with a marked reduction in macrophage infiltration and MCP-1 expressi”