A family of drug transporters: the multidrug resistance-associated proteins.

By P. Borst, R. Evers, Marcel Kool, J. Wijnholds. Journal of the National Cancer Institute, 2000

1,773 citations recorded by the source corpus.

Subfields: Infectious Diseases, Oncology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/d03a66a8f2ebee98f614fe4b90703a5cf6048833

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In Oncology

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Citations in the corpus

Ovarian cancer: strategies for overcoming resistance to chemotherapy (2003, background): “Alterations in drug influx and efflux due to cell-membrane transport proteins such as P-glycoprotein (PGP), multidrug-resistance protein (MRP) and lung-resistance protein (LRP) — members of the ABC transporter proteins — can affect intracellular drug concentration and have been shown to correlate, ”
Molecular mechanisms of cisplatin resistance (2012, background): “Early reports suggested that ABC ATPases like multidrug resistance protein (MRP)1, MRP2, MRP3 and MRP5 would also mediate some extent of cisplatin resistance by increasing cisplatin export (Borst et al., 2000).”
Multidrug resistance in cancer: role of ATP–dependent transporters (2002, background): “The discovery of MRP1 stimulated a genomic search for homologues, leading to the discovery of eight additional members of the ABCC subfamily of transporters, of which six have been studied in some detai”
iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “Reaction with sulfhydryl groups of glutathione, however, makes it susceptible to the multidrug resistance transporter MRP2, which may also determine its intracellular concentration (Borst et al., 2000).”
Prostate Cancer (2018, background): “Gittelman and collaborators [29] similarly evaluated 466 men with a least 1 prior negative prostate biopsy for the effectiveness of PCA3 score in predicting the presence of prostate cancer.”
Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. (2006, background): “Many studies have focused on xenobiotic substrates because of the potential role of the MRPs in clinical drug resistance and in protection against a wide range of environmental toxicants (42, 78, 96, 161, 247, 287).”
The role of ABC transporters in clinical practice. (2003, background): “This transmembrane domain zero (TMD 0) region is felt to be responsible for the organic anion affinity of MRP1 [ 18 ].”
Cisplatin: mode of cytotoxic action and molecular basis of resistance (2003, background): “…resistance-associated (MRP) gene family, composed of at least seven members (MRP1–7), has been a major target of investigations, primarily as several of these ABC membrane proteins have been found in tumor cells and associated with cellular efflux of a variety of drugs (Borst et al., 2000).”
The human ATP-binding cassette (ABC) transporter superfamily. (2001, neutral): “Unlike ABCB1, however, ABCC1 transports drugs that are conjugated to glutathione by the glutathione reductase pathway (Borst et al. 2000).”
The cytoprotective role of the Keap1–Nrf2 pathway (2011, background): “The MRPs are ATP-dependent membrane-associated organic anion transporters; MRP4 is also involved in the export of nucleosides and prostaglandins (Borst et al. 2000; Reid et al. 2003).”