Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis.

By S. Rantapää-Dahlqvist, B. D. de Jong, E. Berglin, G. Hallmans, G. Wadell, H. Stenlund, U. Sundin, W. V. van Venrooij. Arthritis & Rheumatism, 2003

2,088 citations recorded by the source corpus.

Subfields: Rheumatology

View Paper: https://www.semanticscholar.org/paper/d0195b1d8c020364ecd33133d59f9cbcca996dcf

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In Rheumatology

1. Georg Schett
2. T. Neogi
3. Daniel Aletaha
4. P. Tak
5. S. Gaffen

Citations in the corpus

• A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. (2006, background): “antibodies were observed prior to the occurrence of RF in 2 studies of sera obtained before onset of RA (13,14), suggesting that the increase in RF titers may in some of these cases be an event secondary to anticitrulline immunity and immune complex formation involving citrullinated antigens (40).”
• 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative (2010, positive): “Given the presence of autoantibodies, such as rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) (tested as anti-cyclic citrullinated peptide), which can precede the clinical manifestation of RA by many years,”
• Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin. (2012, positive): “This concept also serves to explain why RA patients already show low bone mass at the onset of disease (31) and why bone damage in RA patients with ACPAs is far higher compared with those without ACPAs.”
• Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. (2004, background): “All three of the human autoimmune diseases shown to date to be associated with PTPN22 R620W are characterized by the production of autoantibodies (anti-GAD Abs in T1D, anti-citrulline Abs and rheumatoid factor in RA, and a vast array of autoantibodies in SLE), and the appearance of these antibodies ”
• Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins. (2005, background): “Intriguingly, these antibodies may be detected years before disease onset ( 5 ,6), are stable over time (7), and are associated with joint destruction, the hallmark of RA (8,9).”