Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.

By C. Kyogoku, Carl D. Langefeld, W. Ortmann, Annette Lee, S. Selby, V. Carlton, Monica Chang, Paula S. Ramos, Emily C. Baechler, F. Batliwalla and 12 more. American Journal of Human Genetics, 2004

710 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/91fc4901b9a337628e4bd0150c5dd868acf47e89

How researchers see this paper

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In Genetics

1. T. Kanai
2. K. Matsuoka

In Immunology

1. T. Kanai
2. K. Matsuoka

Citations in the corpus

• New IBD genetics: common pathways with other diseases (2011, background): “R620W PTPN22 variant which is protective in Crohn’s disease,(70) confers susceptibility to SLE.(87) The PRDM1/ATG5 locus is common between Crohn’s disease, ulcerative colitis and SLE.”
• Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes. (2005, neutral): “…in 2,064 white control subjects; 95% CIs are not corrected for the complex patterns of relatedness of cases. b Thirty-two cases from affected sib pair families reported elsewhere (Kyogoku et al. 2004). c Forty-three cases from affected sib pair families reported elsewhere (Begovich et al. 2004).”