Design properties of hydrogel tissue-engineering scaffolds

By Junmin Zhu, R. Marchant. Expert Review of Medical Devices, 2011

1,352 citations recorded by the source corpus.

This article summarizes the recent progress in the design and synthesis of hydrogels as tissue-engineering scaffolds. Hydrogels are attractive scaffolding materials owing to their highly swollen network structure, ability to encapsulate cells and bioactive molecules, and efficient mass transfer. Various polymers, including natural, synthetic and natural/synthetic hybrid polymers, have been used to make hydrogels via chemical or physical crosslinking. Recently, bioactive synthetic hydrogels have emerged as promising scaffolds because they can provide molecularly tailored biofunctions and adjustable mechanical properties, as well as an extracellular matrix-like microenvironment for cell growth and tissue formation. This article addresses various strategies that have been explored to design synthetic hydrogels with extracellular matrix-mimetic bioactive properties, such as cell adhesion, proteolytic degradation and growth factor-binding.

Subfields: Biomaterials, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/d004fcfe9123147275225f168bff218dec529d60

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In Biomaterials

In Molecular Medicine

Jason A. Burdick

Citations in the corpus

In situ Forming Injectable Hydrogels for Drug Delivery and Wound Repair (2018, neutral): “These materials can bederived frombothnatural and synthetic sources [2].”
Preparation and characterization of nanocellulose reinforced semi-interpenetrating polymer network of chitosan hydrogel (2017, background): “1a, glutaraldehyde can be easily crosslinked with chitosan to form Schiff base linkages (–C=N) because of its two active aldehyde groups (Zhu and Marchant 2011).”
3D Bioprinting for Engineering Complex Tissues (2015, background): “Synthetic polymers, unlike natural polymers, are made through chemical synthesis and are typically more controllable in terms of their chemical and mechanical properties (Zhu and Marchant, 2011).”
Biofabrication: A Guide to Technology and Terminology. (2017, background): “, collagen, gelatin, hyaluronic acid), either in combination with additional biological factors or used alone, are intrinsically biocompatible and biodegradable, and possess biological cues [39].”