Immunohistochemical expression of melan-A and tyrosinase in uveal melanoma
By B. Fernandes, A. Odashiro, V. Saraiva, Patrick T. Logan, E. Antecka, M. Burnier. Journal of Carcinogenesis, 2007
1,224 citations recorded by the source corpus.
Background Melan-A and tyrosinase are new immunohistochemical markers that can be used in the diagnosis of melanocytic lesions. The aim of this study was to investigate the correlation between radiotherapy or clinicohistopathological parameters and the expression of melan-A and tyrosinase in uveal melanoma. Methods Thirty-six enucleated cases of uveal melanoma were studied. The formalin-fixed, paraffin-embedded specimens were immunostained with monoclonal antibodies against melan-A and tyrosinase. The samples were classified as either positive or negative. The chi-square or the Student-t tests were used to test for the correlation of the expression rates of melan-A and tyrosinase with clinico-pathological parameters. Results Melan-A and tyrosinase were positive in 33 (91.7%) and 35 (97.2%) of the specimens, respectively. There was no significant association between the expression of melan-A or tyrosinase and radiotherapy or any clinico-pathological parameter. All specimens were positive for at least one of the immunohistochemical markers. Conclusion To the best of our knowledge this is the first study concluding that the expression of melanocytic markers such as melan-A and tyrosinase is not influenced by radiotherapy or any clinico-pathological parameter. Moreover, when tyrosinase and melan-A are used together, 100% of the formalin-fixed, paraffin-embedded uveal melanoma samples tested positive for one of those markers.
Subfields: Cell Biology, Genetics, Ophthalmology
View Paper: https://www.semanticscholar.org/paper/192ed9d31378f1d1af0b86baeafccc42146ab3fb
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cell Biology
Citations in the corpus
- Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells (2008, background): “Cancer cells produce higher levels of ROS than normal cells, and this contributes to cancer progression.(14,17,18) Trachootham et al.”
- Titanium dioxide nanoparticles: a review of current toxicological data (2013, background): “Elevated levels of ROS and down regulation of ROS scavengers and antioxidant enzymes are associated with various cancers [203].”
- Oxidative Stress in Aging Human Skin (2015, background): “Other redox sensitive “switches” are transcription factors such as AP-1, NF- B, NF-E2 related factor-1 (Nfr1), NF-E2 related factor-2 (Nrf2) and Egr1 (early growth response 1) [306,321,322] that modulate gene expression [298] which”
- Drug-Induced Oxidative Stress and Toxicity (2012, background): “Tumour cells have high levels of ROS, and studies have shown elevated levels of oxidative stress and/or oxidative DNA damage in human malignancies relative to normal cells [4, 5].”
- Antioxidant Properties of Probiotic Bacteria (2017, background): “Sources of reactive oxygen species (ROS) (referred to [21]).”