Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action

By T. Lauer, M. Preik, T. Rassaf, B. Strauer, A. Deussen, M. Feelisch, M. Kelm. Proceedings of the National Academy of Sciences of the United States of America, 2001

610 citations recorded by the source corpus.

Subfields: Biochemistry, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/cfeb62b1f329edf3460e1dd9eab4b5a7893e0c45

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. E. Weitzberg
2. N. Bryan
3. J. Lundberg
4. M. Grisham

In Physiology

1. E. Weitzberg
2. N. Bryan
3. J. Lundberg
4. N. Benjamin
5. F. Larsen
6. B. Ekblom

Citations in the corpus

• Methods to detect nitric oxide and its metabolites in biological samples. (2007, background): “Nitrite and nitrate in blood have been widely used as an index of endothelial NO synthase activity [38,39] as routine indirect measures of NO levels.”
• The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics (2008, background): “, a physiological role of this anion in vasoregulation has been dismissed, even in more recent studie”
• Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation (2003, background): “Indeed, no vasodilatory effects were reported when nitrite was infused into the forearm circulation of three human subjects for 1 min (ref”
• Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver. (2005, neutral): “However, within physiological ranges of pH and oxygen tension, nitrite has been considered an inert metabolic end product of NO oxidation with limited intrinsic biological activity (14).”
• Nitrate, bacteria and human health (2004, background): “Under basal conditions, the metabolites of endogenous NO in plasma are mainly derived from the L -arginine-NO pathway in the endothelium of blood vessel”
• Renal ischemia/reperfusion injury; from pathophysiology to treatment (2015, background): “The anion nitrite is an end product of NO metabolism (89).”