Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation

By K. Cosby, Kristine S Partovi, J. Crawford, R. Patel, C. Reiter, S. Martyr, Benjamin K. Yang, M. Waclawiw, G. Zalos, Xiuli Xu and 6 more. Nature Medicine, 2003

1,816 citations recorded by the source corpus.

Subfields: Cell Biology, Endocrine and Autonomic Systems, Physiology

View Paper: https://www.semanticscholar.org/paper/16bca353b42241a0b581c06d6f545547eaa1f037

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Rakesh K. Jain

In Endocrine and Autonomic Systems

1. E. Weitzberg
2. F. Larsen
3. B. Ekblom
4. J. Lundberg
5. Emmelie A Jansson
6. M. Govoni
7. D. Lefer

In Physiology

1. E. Weitzberg
2. J. Lundberg
3. F. Larsen
4. B. Ekblom
5. N. Bryan
6. Emmelie A Jansson
7. M. Govoni
8. Rakesh K. Jain

Citations in the corpus

• The microcirculation is the motor of sepsis (2005, background): “Red blood cells also play an important role in the regulation of microcirculatory blood flow by their ability to release NO in the presence of hypoxia and cause vasodilation [22,23].”
• Effects of dietary nitrate on oxygen cost during exercise (2007, background): “Cosby et al. (2003) described NO formation and vasodilation from the reaction of circulating nitrite ions with deoxyhaemoglobin in blood.”
• The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash. (2008, background): “A picture is now emerging suggesting important physiological functions of the nitrite-NO pathway in regulation of blood flow [6,7], gastric integrity [8–11] and in tissue protection against ischemic injury [12,13].”
• Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver. (2005, positive): “Based on these data, a role for circulating nitrite in mediating hypoxic vasodilation was proposed, with the oxygen sensor in this case being hemoglobin (8).”
• Methods to detect nitric oxide and its metabolites in biological samples. (2007, positive): “The nitrite reductase activity in mammalian tissues has been linked to the mitochondrial electron transport system [17–21], protonation [16,22], deoxyhemoglobin [22,23], and xanthine oxidase [24–26].”
• The role of nitric oxide in tumour progression (2006, background): “The reduction of nitrite to NO by deoxyhaemoglobin and NO release from S- nitrosohaemoglobin preferentially occur at low oxygen tensio”