The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics

By J. Lundberg, E. Weitzberg, M. Gladwin. Nature reviews. Drug discovery, 2008

2,641 citations recorded by the source corpus.

Subfields: Biochemistry, Biophysics, Physiology

View Paper: https://www.semanticscholar.org/paper/93b6093a26bac3a14837bb0c77b77cbff8e1c1d6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. E. Weitzberg
2. J. Lundberg
3. F. Larsen
4. B. Ekblom
5. Emmelie A Jansson
6. M. Govoni
7. N. Bryan
8. K. Sahlin

In Physiology

1. E. Weitzberg
2. J. Lundberg
3. F. Larsen
4. B. Ekblom
5. N. Bryan
6. Emmelie A Jansson
7. M. Govoni
8. K. Sahlin

Citations in the corpus

• Dietary inorganic nitrate improves mitochondrial efficiency in humans. (2011, background): “Cell M been increasingly appreciated (Gladwin et al., 2005; Lundberg et al., 2008; van Faassen et al., 2009).”
• Ischemia and reperfusion—from mechanism to translation (2011, background): “Multiple studies have implicated the endogenous production of NO or its therapeutic application in attenuating ischemia-reperfusion injur”
• A review of soil NO transformation: associated processes and possible physiological significance on organisms (2015, background): “…tract cells and 1372 increase the level of available NO, which together with endogenous 1373 produced NO by the host may be involved in vasodilation, vasoprotection, 1374 cytoprotection, neuroprotection, etc. (Lundberg et al., 1994, 2008; 1375 Velayutham and Zweier, 2013 and references therein).”
• Agroecosystem Management and Nutritional Quality of Plant Foods: The Case of Organic Fruits and Vegetables (2011, background): “…increasing number of studies indicate that and how plant-derived nitrate may provide significant benefits for human health (McKnight et al., 1999; Lundberg et al., 2008), quantitative data on consequences for health of the consumer are scarce and controversial, and some data are being published…”
• The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash. (2008, background): “Nitrite can be converted to NO via reactions with deoxyhemoglobin, deoxymyoglobin, xanthine oxidoreductase, enzymes of the mitochondrial repiratory chain, and by acidic reduction which is enhanced by antioxidant conditions [1].”
• Food sources of nitrates and nitrites: the physiologic context for potential health benefits. (2009, background): “These enzymes synthesize nitric oxide from the amino acid L-arginine and molecular oxygen to accomplish vasodilation, blood pressure regulation, inhibition of endothelial inflammatory cell recruitment, and platelet aggregation (21).”