Widespread recombinase expression using FLPeR (Flipper) mice

By F. W. Farley, Philippe Soriano, L. Steffen, S. Dymecki. Genesis, 2000

642 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/cfc8f86b18085fbc3781132e6182a3e3632e1f19

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Citations in the corpus

Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination (2006, background): “1 ) in mice transgenic for Flp recombinase, which recombine frt sites early in embryogenesi”
Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh (2009, background): “1a ) includes the 5′ homology arm (10,942 bp, a Hin dIII fragment, position 59,108–70,060 in BAC, Genbank accession number AL606746 ), the 5′ loxP site, the Hin dIII- Sal I fragment containing the Sox2 gene (position 70,060–76,650), the 3′ loxP site, a neomycin-resistance cassette flanked b”
Conditional Knock-Out of Kir4.1 Leads to Glial Membrane Depolarization, Inhibition of Potassium and Glutamate Uptake, and Enhanced Short-Term Synaptic Potentiation (2007, background): “This transgene was integrated into the ROSA26 locus, which has been shown to drive transgene expression in most cells, including germ line (Farley et al., 2000).”
Transcription factor achaete scute-like 2 controls intestinal stem cell fate. (2009, methodology): “flanked by Frt recombination sites and excised in vivo by crossing the mice with the FLPeR deleter stain (Farley et al., 2000).”
Mitochondrial Fusion Protects against Neurodegeneration in the Cerebellum (2007, neutral): “Founder chimeric mice were bred to Black Swiss mice, and agouti offspring were bred to FLPeR mice (Farley et al., 2000) to remove the neomycin resistance cassette.”
The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium (2009, positive): “Scgb1a1-CreER mice were crossed with FLPeR mice (Farley et al., 2000) to remove the Neo cassette”
Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases (2016, methodology): “The PGKneo cassette was subsequently removed by breeding germline mice to FLPeR (Farley et al., 2000) mice expressing Flp recombinase from the Rosa26 locus (C57BL/6J genetic background).”