Induction of Dendritic Cell Differentiation by IFN-α in Systemic Lupus Erythematosus

By P. Blanco, A. Palucka, Michelle A. Gill, Virginia Pascual, Jacques Banchereau. Science, 2001

1,240 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/cfb14f5f6fe36f04d3feddb20c3f207be29499dc

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In Immunology

In Rheumatology

Citations in the corpus

Activation of the interferon-alpha pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease. (2005, result): “These data, along with the findings from the logistic regression analysis, indicate that the proposed in vivo activation of SLE monocytes by IFN (15), as well as the lymphopenia of patients with active SLE, may be factors in the elevated IFIG expression in some patients.”
Skin immune sentinels in health and disease (2009, background): “pDCs are rare in healthy skin but have been implicated in the pathogenesis of systemic lupus erythematosus and psoriasi”
Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade (2005, background): “Incubation of healthy PBMCs with SoJIA serum up-regulates transcription of innate immunity genes We have previously shown that interferon- � , which is present in the serum of patients who have systemic lupus erythematosus (SLE), induces the differentiation of healthy monocytes into dendritic cells ”
Plasmacytoid predendritic cells initiate psoriasis through interferon-α production (2005, background): “Upon viral stimulation, PDCs differentiate into DCs (11, 12) and/ or induce an IFN- � ‐dependent maturation of bystander myeloid DCs with the ability to drive Th1 responses ( 13 ), thus providing a unique link between innate and adaptive antiviral immunity.”
Vaccine Adjuvants: Putting Innate Immunity to Work (2010, background): “Type I IFNs play a critical role in enhancing T and B cell immunity with dsRNA through a variety of mechanisms that include activation of DCs, NK cells, and direct effects on T cells (Blanco et al., 2001; Le Bon et al., 2006; Longhi et al., 2009).”