Decreased bioavailability of vitamin D in obesity.

By J. Wortsman, L. Matsuoka, Tai C. Chen, Zhiren Lu, M. Holick. American Journal of Clinical Nutrition, 2000

3,363 citations recorded by the source corpus.

Subfields: Epidemiology, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/cf8fb6615dbba542fa0c4578668a121799472da3

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Citations in the corpus

IOF position statement: vitamin D recommendations for older adults (2010, background): “It is smaller in subjects with high BMI than in individuals with normal BMI [3, 4].”
Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. (2005, background): “(11), the capacity of the skin to produce vitamin D was not altered in obesity.”
Vitamin D—Effects on Skeletal and Extraskeletal Health and the Need for Supplementation (2013, background): “lipophilic vitamin D in the fat tissue [23,166,169,170], potentially explaining the described correlations [166].”
Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. (2007, background): “34-36 The effect of vitamin D on adiposites and adipokines is unclear.”
The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. (2012, neutral): “number of mechanisms are plausible (90, 91).”
Vitamin D deficiency: a worldwide problem with health consequences. (2008, background): “Obesity is associated with vitamin D deficiency, and it is believed to be due to the sequestration of vitamin D by the large body fat pool (44).”
The clinician’s guide to prevention and treatment of osteoporosis (2022, background): “This regimen should be followed bymaintenance therapy of 1000 to 2000 units/day or whatever dose is needed to maintain the target serum level [113, 114].”
Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors. (2007, background): “(12), a well-known risk factor for hypovitaminosis D (13, 14), may adversely affect vitamin D status in the population.”
The vitamin D epidemic and its health consequences. (2005, background): “Thus, obese individuals are only able to increase their blood levels of vitamin D 50% compared with normal weighted individuals (34) (Fig.”
The epidemiology of vitamin D and cancer incidence and mortality: A review (United States) (2005, background): “insufficiency is probably due to decreased bioavailability of 25(OH)D due to its deposition in body fat compart ments [43].”
Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988-1994. (2002, background): “An association between obesity and hypovitaminosis D was reported previously for young white adults (37, 40, 41).”
Adiposity, Cardiometabolic Risk, and Vitamin D Status: The Framingham Heart Study (2009, positive): “Furthermore, experimental studies indicate that differences in sunlight exposure are not enough to account for the differences in vitamin D concentrations seen between obese and nonobese volunteers (12).”
The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults. (2004, background): “BMI has also been inversely correlated with peak serum vitamin D3 levels after exposure of the skin surface to irradiation and with peak serum vitamin D2 levels after oral ingestion of vitamin D2 (5, 15).”
Vitamin D in preventive medicine: are we ignoring the evidence? (2003, neutral): “1985 ; Wortsman et al .”