The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy.
By R. Knöll, M. Hoshijima, H. Hoffman, V. Person, I. Lorenzen‐Schmidt, M. Bang, Takeharu Hayashi, N. Shiga, H. Yasukawa, W. Schaper and 11 more. Cell, 2002
821 citations recorded by the source corpus.
Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/cf3d217b90a694fd1a3f0a6f7e476bc745d09bc8
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In Cardiology and Cardiovascular Medicine
In Molecular Biology
Citations in the corpus
- Adhesion-dependent cell mechanosensitivity. (2003, background): “The focal adhesion mechanosensor is probably not a unique molecular machine but a prototypic device, which can have analogs in other cellular systems such as adherens junction complex (Ko & McCulloch 2001) and the Z-disc-complex in striated muscle (Epstein & Davis 2003, Knoll et al. 2002).”
- Zebrafish as a model to study cardiac development and human cardiac disease (2011, background): “One mechanism underlying the development of DCM is defective cardiac stretch sensing.(70) Several zebrafish mutants have been identified that display heart phenotypes resembling the features of human cardiomyopathies, and their characterization has provided a better understanding of the human diseas”
- The vertebrate muscle Z-disc: sarcomere anchor for structure and signalling (2009, background): “In mice muscles deficient of muscle LIM protein (MLP; description later), the Z-bands in cardiac muscle were frequently irregular and widened (Knoll et al. 2002).”
- Sense and stretchability: the role of titin and titin-associated proteins in myocardial stress-sensing and mechanical dysfunction. (2007, background): “MLP-null mice develop DCM 2–4 weeks postnatally and have cardiomyocytes with widened and disorganized Z-disks.(44) In MLP-null hearts the PT of papillary muscles was reduced,(44) myocardial passive stiffness was decreased, and relaxation time was prolonged, but no alterations were found in most syst”