The vertebrate muscle Z-disc: sarcomere anchor for structure and signalling
By Pradeep K. Luther. Journal of Muscle Research and Cell Motility, 2009
179 citations recorded by the source corpus.
The Z-disc, appearing as a fine dense line forming sarcomere boundaries in striated muscles, when studied in detail reveals crosslinked filament arrays that transmit tension and house myriads of proteins with diverse functions. At the Z-disc the barbed ends of the antiparallel actin filaments from adjoining sarcomeres interdigitate and are crosslinked primarily by layers of α-actinin. The Z-disc is therefore the site of polarity reversal of the actin filaments, as needed to interact with the bipolar myosin filaments in successive sarcomeres. The layers of α-actinin determine the Z-disc width: fast fibres have narrow (~30–50 nm) Z-discs and slow and cardiac fibres have wide (~100 nm) Z-discs. Comprehensive reviews on the roles of the numerous proteins located at the Z-disc in signalling and disease have been published; the aim here is different, namely to review the advances in structural aspects of the Z-disc.
Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/210aca234ce61938ff08ae8c69d2fba8ce2b019e
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In Cardiology and Cardiovascular Medicine
Citations in the corpus
- 2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy. (2019, background): “The Z-disc provides structural support by tethering the sarcomere to the sarcolemma via the costameres and by anchoring filamentous F-actin, titin, and nebulette.(305) As one of the integral Z-disc proteins, a-actinin has a myriad of binding partners, with each interaction serving a distinct role in”