A Transgenic Model for Listeriosis: Role of Internalin in Crossing the Intestinal Barrier

By Marc Lecuit, S. Vandormael-Pournin, J. Lefort, M. Huerre, P. Gounon, C. Dupuy, C. Babinet, P. Cossart. Science, 2001

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Listeria monocytogenes: a multifaceted model (2006, background): “Consequently, a novel animal system was developed to study the crossing of the intestinal barrier: a transgenic mouse that expresses human E-cadherin on the surface of enterocyte”
Listeria monocytogenes virulence and pathogenicity, a food safety perspective. (2002, background): “The guinea pig, which has a functional receptor, has been proposed as a better model in this regard (108, 109).”
Bacterial adhesion and entry into host cells. (2006, neutral): “Traversal of the intestinal barrier and of the feto-placental barrier by subversion of cellular E-cadherin function by InlA has been established (Lecuit et al., 2001, 2004), and it is suspected that traversal of the blood-brain barrier probably also requires InlA/E-cadherin interactions.”
How bacterial pathogens colonize their hosts and invade deeper tissues. (2015, background): “In the case of Listeria, interaction between the bacterial InlA surface protein and the host receptor E-cadherin is essential for crossing of the intestinal barrier [54,79].”