Signal transduction to hypoxia-inducible factor 1.

By G. Semenza. Biochemical Pharmacology, 2002

893 citations recorded by the source corpus.

Subfields: Sociology and Political Science

View Paper: https://www.semanticscholar.org/paper/ceda9f362160a678a781d1d7648055a79f00de0f

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In Sociology and Political Science

1. Jianping Ye
2. Robert A. Gatenby
3. Jun-yi Yin
4. Qing He
5. N. Ferrara
6. Zhanguo Gao
7. Robert James Gillies

Citations in the corpus

• Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. (2007, methodology): “HFD, high-fat diet; CR, calorie restriction; BW, body weight; HIF-1 , hypoxia-inducible factor-1 ; GLUT1, glucose transporter 1; Hemox, heme oxygenase 1; PDK1, pyruvate dehydrogenase kinase 1.”
• Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis. (2005, background): “This ubiquitination is mediated by the von Hippel-Lindau protein (pVHL), the recognition component of an E3 ubiquitin ligase (Semenza, 2002).”
• mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways (2004, methodology): “To further explore this finding, GSEA was carried out using a list independently curated from the literature of putative Hif-1α transcriptional target gene”
• HIF-1 as a target for drug development (2003, background): “This overexpression of HIF-1α is due to both hypoxia-dependent as well as hypoxia-independent pathways, such as oncogene activation and glucose deprivatio”
• The biology of VEGF and its receptors (2003, background): “It is now well established that hypoxia-inducible factor (HIF)-1 is a key mediator of hypoxic response”
• Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL (2003, background): “Finally, activation of HIF is also the result of intratumoral hypoxia and non- VHL oncogenic pathway”
• Why do cancers have high aerobic glycolysis? (2004, background): “Although it is termed the hypoxia-inducible factor, HIF1α levels can in fact be stabilized by a range of factors, including cyclooxygenase-2 activity, insulin-like growth factor 2, ERBB2, epidermal growth factor receptor, phosphatidylinositol 3-kinase, heat-shock protein 90, microtubule status, thio”
• Angiogenesis in Cancer (2006, neutral): “…Furudoi et al 2002), breast cancer (Kurebayashi et al 1999; Gunningham et al 2000; Kinoshita et al 2001; Skobe et al 2001), lung cancer (Decaussin et al 1999; Niki et al 2000; Kajita et al 2001), head and neck squamous cell carcinoma (O-charoenrat et al 2001), Kaposi sarcoma (Jussila et al…”