Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis.

By B. Kaur, F. Khwaja, E. Severson, S. Matheny, D. Brat, Erwin G. Van Meir. Neuro-Oncology, 2005

660 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Cancer stem cells in glioblastoma (2015, background): “…epitope, should be used with care to enrich for any cells: Surface CD133 marks stem cells and decreases with differentiation, but the expression of Prominin-1 mRNA is not regulated with stemness (Kemper et al. 2010), suggesting that only the glycosylated surface proteinCD133 is CSC-specific.”
Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. (2006, background): “Angiogenesis is critical to tumor formation and maintenance (1).”
Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells (2009, positive): “Another family member, HIF3a, lacks the transcriptional activation domain and functions as a dominant negative regulator of the hypoxia response due to sequestration of HIFbs (Kaur et al., 2005).”