Aneuploidy and cancer

By S. Sen. Current Opinion in Oncology, 2000

713 citations recorded by the source corpus.

Subfields: Cell Biology, Genetics, Oncology

View Paper: https://www.semanticscholar.org/paper/ceda15005065843663c6c3a99313fe7bf8ba7ae1

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Citations in the corpus

Chromosome instability is common in human cleavage-stage embryos (2009, methodology): “A new algorithm corrected intensity ratios for clone-speciﬁc ampliﬁcation biases and subsequently determined for each clone a smoothed posterior probability of being normal diploid, deleted and duplicated in the analyzed single cell.”
Forkhead Box M1 Regulates the Transcriptional Network of Genes Essential for Mitotic Progression and Genes Encoding the SCF (Skp2-Cks1) Ubiquitin Ligase (2005, background): “It is interesting that Foxm1 / MEFs generated by Medema and colleagues exhibit aneuploid genotypes (37), which are a hallmark of neoplastic transformation (58, 62).”
Genomic instability — an evolving hallmark of cancer (2010, background): “However, efforts to identify caretaker genes, the inactivation of which leads to genomic instability in sporadic (non-hereditary) cancers, have met with limited succes”
Allele-specific copy number analysis of tumors (2010, background): “Complicating factors are that tumor cells are often aneuploid (9, 10) and that tumor samples contain multiple populations of both tumor and nontumor cells (11, 12).”
Biological activities and molecular targets of the human papillomavirus E7 oncoprotein (2001, background): “…an early event that importantly contributes to carcinogenic progression whereas other investigators have argued that aneuploidization occurs as a late step and is a consequence of cell cycle dysfunction that is of limited functional signi®cance for tumorigenic progression (reviewed in Sen, 2000).”
Merotelic Kinetochore Orientation Is a Major Mechanism of Aneuploidy in Mitotic Mammalian Tissue Cells (2001, methodology): “In addition, recent studies have indicated that aneuploidy in somatic mitotic cells plays a significant role in tumorigenesis (for review see Sen, 2000).”
A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays. (2005, background): “As tumor samples frequently exhibit complex chromosome abnormalities with extensive genetic imbalances (22), analysis of tumor specimens requires additional considerations in selection of references.”