Biological activities and molecular targets of the human papillomavirus E7 oncoprotein

By K. Münger, J. Basile, S. Duensing, A. Eichten, Sonia L. Gonzalez, M. Grace, V. Zacny. Oncogene, 2001

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Cell cycle regulation: p53-p21-RB signaling (2022, background): “Oncoproteins from small DNA tumor viruses such as adenovirus E1A protein, simian virus SV40 large tumor antigen, and human papillomavirus HPV E7 protein disrupt the interaction of RB with the E2F transcription factor family [7, 8].”
The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. (2002, background): “…a definite causalthe tumor suppressor functions of retinoblastoma (Rb) family proteins, resulting in increased activity of E2F relationship between the initial polarization and the subsequent onset of luminal apoptosis in MCF-10A acini.transcription factors (Munger et al., 2001; Sherr, 1996).”
The papillomavirus life cycle. (2005, background): “Both E6 and E7 have functions that stimulate cell cycle progression and both can associate with regulators of the cell cycle (Munger et al., 2001).”
iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “Other key regulators of the cell cycle that are known interacting partners of E7 include the p21/p27 cdk inhibitors, and a subset of cyclins (Münger et al., 2001).”