Injectable, Cellular-Scale Optoelectronics with Applications for Wireless Optogenetics

By Tae‐il Kim, J. McCall, Yei Hwan Jung, Xian Huang, E. Siuda, Yuhang Li, Jizhou Song, Y. Song, Hsuan An Pao, Rak-Hwan Kim and 11 more. Science, 2013

1,108 citations recorded by the source corpus.

The Smaller, the Better New semiconductor device technology enables injection of light-emitting diodes, silicon devices, actuators, and sensors at precisely controlled locations within biological tissues, such as the brain. Kim et al. (p. 211) show how wireless control of animal models using these technologies and the techniques of optogenetics provide new insights into basic behavioral neuroscience. Miniaturized and implantable light-emitting diodes offer precise and flexible control of neurons, when used in combination with optogenetics. Successful integration of advanced semiconductor devices with biological systems will accelerate basic scientific discoveries and their translation into clinical technologies. In neuroscience generally, and in optogenetics in particular, the ability to insert light sources, detectors, sensors, and other components into precise locations of the deep brain yields versatile and important capabilities. Here, we introduce an injectable class of cellular-scale optoelectronics that offers such features, with examples of unmatched operational modes in optogenetics, including completely wireless and programmed complex behavioral control over freely moving animals. The ability of these ultrathin, mechanically compliant, biocompatible devices to afford minimally invasive operation in the soft tissues of the mammalian brain foreshadow applications in other organ systems, with potential for broad utility in biomedical science and engineering.

Subfields: Biomedical Engineering, Cellular and Molecular Neuroscience

View Paper: https://www.semanticscholar.org/paper/cea46a2c8c7b7321a1609a47a8abd551db16ca03

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In Biomedical Engineering

In Cellular and Molecular Neuroscience

Citations in the corpus

Memory Engram Cells Have Come of Age. (2015, positive): “…in a not so distant future, we may even be able to combine the knowledge obtained by these studies with minimally invasive technologies such as wireless optogenetics (Kim et al. 2013) and magnetogenetics (Chen et al. 2015) to develop novel therapeutic methods for a variety of brain disorders.”
High-density, long-lasting, and multi-region electrophysiological recordings using polymer electrode arrays (2018, positive): “Polymer arrays can also provide a neural interface that is biocompatible (Jeong et al., 2015; Kim et al., 2013; Lee et al., 2017a; Luan et al., 2017) and flexible enough to counteract micromotions of the array relative to the brain (Gilletti and Muthuswamy, 2006).”
Advances in small lasers (2014, neutral): “ττpp = cc ααii +(1 (2LL)) ⁄ ln(RR1RR2) nn = 2ππππ QQλλ0 (5)”
Syringe injectable electronics (2015, methodology): “(12) The photoresist protection was removed from nanowire device meshes by exposure to ultraviolet light (430 nm, 120 s) and immersion in developer solution (MF-CD-26, MicroChem Corp.”
MicroLED technologies and applications: characteristics, fabrication, progress, and challenges (2020, neutral): “MicroLED has potential in biomedical and health applications due to its comparable size with neurons, high response frequency, flexible display, and array integration [16].”
Flexible near field wireless optoelectronics as subdermal implants for broad applications in optogenetics (2017, positive): “This methodology is considered as essential for current efforts in neuroscience research largely due to its capabilities for sophisticated functional studies in the central and peripheral nervous systems (Bonin et al., 2015; Boyden et al., 2005; Iyer et al., 2014; Kim et al., 2013; Sparta et al., 20”