High-density, long-lasting, and multi-region electrophysiological recordings using polymer electrode arrays
By Jason E. Chung, Hannah R. Joo, Jiang Lan Fan, Daniel F. Liu, A. Barnett, Supin Chen, Charlotte Geaghan-Breiner, Mattias P. Karlsson, Magnus Karlsson, K. Lee and 7 more. Neuron, 2018
303 citations recorded by the source corpus.
Summary The brain is a massive neuronal network, organized into anatomically distributed sub-circuits, with functionally relevant activity occurring at timescales ranging from milliseconds to months. Current methods to monitor neural activity, however, lack the necessary conjunction of anatomical spatial coverage, temporal resolution, and long-term stability to measure this distributed activity. Here we introduce a large-scale, multi-site, extracellular recording platform that integrates polymer electrodes with a modular stacking headstage design supporting up to 1024 recording channels in freely behaving rats. This system can support months-long recordings from hundreds of well-isolated units across multiple brain regions. Moreover, these recordings are stable enough to track large numbers of single units for over a week. This platform enables large-scale electrophysiological interrogation of the fast dynamics and long-timescale evolution of anatomically distributed circuits, and thereby provides a new tool for understanding brain activity.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience
View Paper: https://www.semanticscholar.org/paper/100b3f61338adbaea71c2c3da514ec0a6ba97b09
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Citations in the corpus
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- Approaches of wearable and implantable biosensor towards of developing in precision medicine (2024, background): “These devices can record more information about an individual’s brain state, making treatment more informative and effective (94, 95).”