Mechanisms of resistance to quinolones.

By G. Jacoby. Clinical Infectious Diseases, 2005

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Pseudomonas Aeruginosa: Resistance to the Max (2011, background): “Jacoby, G. A. (2005). Mechanisms of resistance to quinolones.”
Acquired Antibiotic Resistance Genes: An Overview (2011, background): “The chromosome-encoded resistance result in either a decreased outer-membrane permeability related to porin loss, to the (over)expression of naturally occurring efflux pumps or mutations of the molecular targets DNA gyrase and topoisomerase IV (Hooper, 2000; Ruiz, 2003; Jacoby, 2005).”
Plasmid-Mediated Quinolone Resistance: a Multifaceted Threat (2009, background): “125 g/ml; E coli J53 carrying a qnrA plasmid has an MPC that is more than 10-fold greater (88) (Fig.”
The Pervasive Effects of an Antibiotic on the Human Gut Microbiota, as Revealed by Deep 16S rRNA Sequencing (2008, background): “This result is not surprising when we consider that antibiotic resistance, even high-level Cp resistance resulting from chromosomal mutations [87], can be acquired far more rapidly than the rate of evolutionary change in the 16S rRNA gene.”