PD-1 Expression in Acute Hepatitis C Virus (HCV) Infection Is Associated with HCV-Specific CD8 Exhaustion
By S. Urbani, B. Amadei, D. Tola, M. Massari, S. Schivazappa, G. Missale, C. Ferrari. Journal of Virology, 2006
626 citations recorded by the source corpus.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/ce1ca582ec173f1b54466470dc56528a96e8c320
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Citations in the corpus
- Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity (2010, background): “…chronically infected with HIV (Day et al., 2006; Petrovas et al., 2006; Trautmann et al., 2006), hepatitis B virus (Boettler et al., 2006), and hepatitis C virus (HCV; Urbani et al., 2006) express high levels of PD-1, and blocking of PD-1–PD-L interactions can restore T cell function in vitro.”
- PD-1 and PD-1 ligands: from discovery to clinical application. (2007, background): “In addition to HIV infection, Urbani et al. and Radziewicz et al. reported that PD-1-expressing exhausted CD8 T cells are also found in hepatitis C virus-infected patients ( 73 , 74).”
- PD-1 and its ligands in tolerance and immunity. (2008, background): “Blocking PD1:PD-L interactions in vitro reverses the exhaustion of HIV-specific, HBV-specific (92), HCV-specific, and SIV-specific (97) CD8 and CD4 T cells and restores proliferation and cytokine production (23, 89, 90, 93).”
- Characterization of Hepatitis B Virus (HBV)-Specific T-Cell Dysfunction in Chronic HBV Infection (2007, background): “Thus, in addition to those to lymphocyte choriomeningitis virus (1), HIV (8, 23, 30), and hepatitis C virus (32) infections, the blocking of PD-1/PD-L1 is able to improve, at least in vitro, the efficiency of the antiviral immune response to chronic HBV infection, confirming the importance of the PD”
- CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer. (2019, background): “In contrast, in chronic infections and cancer PD-1 expression is maintained at high levels on Tex cells (15, 45, 69, 95, 134, 215).”